Download Richard Searles mp3

Artist: Richard Searles: mp3 download    Genre(s):  Celtic     Discography:      Celtic Cross    Year: 1995    Tracks: 19      Ancient Isles    Year: 1993    Tracks: 11      Emerald Castles    Year: 1992    Tracks: 14      Earth Quest    Year: 1990    Tracks: 11 Although primitively a classically trained guitar player, Richard Searles has been known to incorporate elements of such varied sounds as Celtic, Renaissance, and existence music into his music that often results in a reposeful raw age portmanteau word of honor. Searles hails from Los Angeles, CA, but developed an interestingness group in such alien musical styles from his have personal travels through and through Great Britain, Africa, Asia, and the Middle East. Playing a attractively hand-crafted Mattingly guitar, Searles has steadily issued albums since the late '80s, including such standout titles as 1986's A Christmas Gift, 1990's Earth Quest, 1992's Emerald Castles, and 1997's Scarborough Faire, among others.

Inhibiting Blood Vessel Growth Shows Promise In Rat Model Of Deadly Brain Tumor

�In a landmark cogitation, Medical College of Wisconsin researchers in Milwaukee report card that drugs used to inhibit a specific butterball acid in rat brains with glioblastoma-like tumors not only rock-bottom new blood vessel growth and tumour size dramatically, but likewise prolonged natural selection. The study is the featured cover story of the August, 2008 Journal of Cerebral Blood Flow & Metabolism.


"These rat

Genzyme And Isis Begin Second Phase 3 Trial Of Mipomersen

�Genzyme Corp. (Nasdaq: GENZ) and Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced that they get begun a phase 3 study of mipomersen in
patients with heterozygous familial hypercholesterolemia (heFH), a transmissible
disorder that causes exceptionally high levels of LDL cholesterol. It is
the first of four new trials the companies plan to pioneer by the end of
this year, and the second late-stage study of mipomersen, a novel
lipid-lowering drug that utilizes antisense technology.



The companies besides announced that the United States Patent and
Trademark Office granted the patent entitled "Antisense Modulation of
Apolipoprotein B (apoB) Expression," U.S. Patent No. 7,407,943. The patent
broadly covers the use of antisense compounds targeting the apoB messenger
RNA except a ribozyme.



"We are making excellent advance in implementing our comprehensive
development design for mipomersen," stated John P. Butler, president of
Genzyme's renal, endocrine and cardiovascular business units. "The start of
the heFH study puts us on track to meet our goal of beginning foursome new
mipomersen studies this year. In addition, the recent patent issuance
increases the overall value of mipomersen, which we believe has tremendous
potential to help patients."



The new trial volition evaluate the safety and efficacy of mipomersen in
patients wHO have heFH and coronary thrombosis artery disease. It is a randomised,
double-blind, placebo-controlled study taking place at approximately 30
sites in the U.S. and Canada, with an anticipated amount enrollment of
around one C patients. Patients on a stable venereal infection of other lipid-lowering
agents are organism randomized 2:1 to receive a 200 mg dose of mipomersen or
placebo weekly for 26 weeks. The primary endpoint will be percent simplification
in LDL cholesterol, and data ar expected to be available in 2010. The
run will add together to the body of clinical information on mipomersen and the overall
merchandise profile.



"This is an exciting instant for mipomersen, combining the initiation of
the phase 3 tribulation in heFH with a very broad patent leeway that expands
the patent coverage for the apoB franchise," aforesaid Stanley Crooke, chairman
and chief executive officer of Isis. "This comprehensive patent covers
methods of inhibiting apoB by targeting anyplace on the messenger RNA
including the site to which mipomersen binds, and all healing uses that
might event from lowering apoB."

Mipomersen Development Plan



The initial indicant sought for mipomersen will be for patients with
homozygous FH, and enrolment in a phase 3 trial in this affected role population
is expected to be completed by the end of this year. Data are expected to
be useable in mid-2009 and a U.S. filing for this indication is
anticipated during the second half of 2010.



Genzyme and Isis plan to begin trey additional trials evaluating
mipomersen's safety and efficacy in reducing LDL cholesterol in high-risk
patients during the second half of 2008. These trials will let in: one for
apheresis-eligible patients, and iI for bad, high cholesterin
patients. All three have anticipated trial designs that include a 2:1
randomization ratio of a 200 mg dose of mipomersen or placebo weekly for 26
weeks.



These trials volition continue to build the body of clinical evidence
around mipomersen's value in managing identical high risk of exposure patients. Data from
the trials testament also inform the design of the morbidity and mortality
result study for potential expansion of mipomersen's label to include a
broader group of at-risk, high cholesterol patients on maximally tolerated,
currently uncommitted therapies.



Following the finalization in June of the mipomersen permit and
quislingism agreement between Genzyme and Isis, the mipomersen IND and
all regulatory authority has been transferred to Genzyme. Now that this
transition has taken place, the companies are looking for forward to Genzyme
tics. As
an pioneer in RNA-based drug find and development, Isis is the owner
or exclusive licensee of over 1,500 issued patents world-wide. Additional
information about Isis is available at http://www.isispharm.com.

Genzyme Safe Harbor Statement



This press release contains modern statements, including
without limitation, statements concerning mipomersen's safety and benefits
for patients with high cholesterol, the development plan for mipomersen and
FDA's requirements for its approval. These statements are case to risks
and uncertainties that could cause real results to differ materially from
those forecasted. These risks and uncertainties include, among others: the
timing of farther discussions with FDA regarding the approving of
mipomersen; the timing and content of submissions to and decisions made by
the FDA relating to mipomersen; further analysis of clinical trial information;
the results of other studies; the actual efficacy and safety of mipomersen;
and the risks and uncertainties described in Genzyme's SEC reports filed
under the Securities Exchange Act of 1934, including the factors discussed
under the caption "Risk Factors" in Genzyme's Quarterly Report on Form 10-Q
for the quarter all over March 31, 2008. Genzyme cautions investors not to
place substantial reliance on the innovative statements contained in
this press discharge. These statements speak only as of today's escort and
Genzyme undertakes no obligation to update or revise the statements.

Genzyme(R) is a registered trademark of Genzyme Corporation. All rights
reserved.

Isis Safe Harbor Statement



This press release includes forward-looking statements regarding Isis'
collaboration with Genzyme Corporation, its financial and business enterprise
development activities, and the development, bodily process, therapeutic
potentiality and safety of mipomersen in treating patients with high
cholesterol. Any program line describing Isis' goals, expectations, financial
or other projections, intentions or beliefs is a forward-looking statement
and should be considered an at-risk affirmation, including those statements
that are described as Isis' goals or projections. Such statements ar
subject to certain risks and uncertainties, particularly those inherent in
the process of discovering, developing and commercializing drugs that are
safe and effective for use as human therapeutics, in developing and
commercializing systems to identify infectious organisms that are in effect
and commercially attractive, and in the endeavor of building a business
about such products. Isis' forward looking statements also involve
assumptions that, if they never happen or shew correct, could cause
its results to differ materially from those expressed or implied by such
modern statements. Although Isis' advanced statements
reflect the upright faith sagacity of its management, these statements are
based just on facts and factors currently known by Isis. As a result, you
are cautioned not to rely on these forward-looking statements. These and
other risks concerning Isis' programs are described in additional detail in
Isis' yearly report on Form 10-K for the year all over December 31, 2007, and
its quarterly report on Form 10-Q for the quarter terminated March 31, 2008,
which are on file with the SEC. Copies of these and other documents are
usable from the Company.

Isis Pharmaceuticals is a registered trademark of Isis Pharmaceuticals,
Inc. Ibis Biosciences and Ibis T5000 are trademarks of Ibis Biosciences,
Inc. Regulus Therapeutics is a stylemark of Regulus Therapeutics LLC.


Genzyme Corp
http://www.genzyme.com



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Pharmion Ltd Withdraws Its Marketing Authorisation Application For Orplatna (satraplatin), Europe

�The European Medicines Agency (EMEA) has been formally notified by
Celgene Europe Ltd of Pharmion Ltd's decision to withdraw the
application for a centralised marketing empowerment for the medicine
Orplatna (satraplatin) 10 mg and 50 mg capsules. Orplatna was expected
to be used, in combination with prednisone and prednisolone, in the
intervention of patients with metastatic hormone-refractory prostate gland cancer

Archie Shepp Mal Waldron

   
Artist: Archie Shepp Mal Waldron

   Genre(s): 
Jazz
   

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Discography:


   
 Left Alone Revisited vs. Mal Waldron

   Year: 2002   
Tracks: 10

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Two 4 Pop, Dynamic 4z, Code Q

Spunge

   
Artist: Spunge

   Genre(s): 
Rock: Punk-Rock
   

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Discography:


   
 Pedigree Chump

   Year: 1999   
Tracks: 14

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Rascal Flatts for movie

The country group Rascal Flatts will perform in the upcoming Hannah Montana movie, said a spokeswoman for the group's Lyric Street Records yesterday. The movie, starring Miley Cyrus and her father, Billy Ray Cyrus, is filming in their home state of Tennessee. It's scheduled for release in theatres next year.

The Police to end career on charitable note

The Police [ tickets ] have launched into the final round of dates on their 30th anniversary reunion tour, but they won't put a lid on it until they give something back.The Rock and Roll Hall of Famers have pledged $1 million to New York City's MillionTreesNYC, which will plant 10,000 trees to create new urban forests, according to a press release. The trio has also committed to making their final concert a benefit for NYC public television arts programming."We kicked off our very first American tour at CBGB's in 1978 and this summer, thirty years later, our journey will come full circle as we play our final show here in New York City," The Police said in a joint statement. "We are honored to partner with public television and have a deep respect for their commitment to arts and culture." Details about the fund-raiser will be released at a later date.Last week, The Police kicked off another round of North American shows, and they've got a dozen more dates across the US through the end of the month, including a two-night stand in Hollywood, CA. In early June, they'll jet to Europe for a month and then return stateside for their fond farewell, which comprises another 17 shows stretching from coast to coast. Elvis Costello & The Imposters will fill the opening slot on the US outing, which is listed below. Overseas gigs can be found at The Police's website.The band's reunion trek moved more than 2.5 million tickets in 2007, making it the year's top-grossing tour, according to a press release. Amidst all the hype, speculation had run rampant that The Police would record a new album, but the rockers quashed those rumors, telling various reporters they have no plans to work together once the tour wraps.The Police released their last studio album, "Synchronicity," nearly 25 years ago. Sting, Stewart Copeland and Andy Summers celebrated their 30th anniversary last year with a best-of collection on A&M Records, and they reportedly have plans to release a live DVD comprising recent concert footage shot in South America.

Liam and Victor out of Big Brother

Liam and Victor have become the latest contestants to be evicted from 'Big Brother: Celebrity Hijack'.
Following Jade's eviction last week, Liam was the second housemate to be evicted from the house with Victor the third.
They faced the public vote along with Victor's sister Emilia and Jeremy.
There are now nine contestants left in the house.
More more on 'Big Brother: Celebrity Hijack' read our blog here.

Urban misses out on Country Music Award but awaiting bigger prize

Urban misses out on Country Music Award but awaiting bigger prize

Newly Zealand-born Keith Urban has missed out on two major Academy of Area Medicine (ACM) awards amid a row o'er how the top award was decided.Urban was laughing when he turned up to the awards in Las Vegas with pregnant married woman Nicole Kidman on his arm, simply left empty-handed after Kenny Chesney won the entertainer of the class category.Urban was likewise nominated for tiptop male singer, only lost out on that point too.Distillery, Urban got to perform at the awards ceremony, and he and Kidman cuddled and looked happy as they posed for photographers in front the case.A beaming Kidman told reporters she is "very excited" about the impending nascence of her offset child with Urban.When asked if the infant had been kicking she replied: "Oh yea. Not right now, simply it has been."Urban says the world of becoming a father simply fully hit him when he and Kidman found out the sex activity of their unborn child, which he would non reveal. - AP

Will & Grace star agrees film deal

Will & Grace star agrees film deal

'Will & Grace' sensation Debra Messing has joined the cast of a freshly family drama-comedy called 'Humboldt Park'.
Change reports that the cast of the plastic film likewise includes John Lackland Leguizamo, Alfred the Great Molina, Freddy Rodriguez, Jay Hernandez, Mercedes Ruehl, Luis Guzman, Melonie Bartholomeu Dias and Vanessa Ferlito.
'Humboldt Park' tells the level of three siblings world Health Organization return to the family home for a festive inflict.
Messing will act the wife of Leguizamo's case.
Shooting on the Alfredo De Villa-directed celluloid begins next calendar week in Newmarket.




Sunshine

Murphy joins Juno star in thriller

Murphy joins Juno star in thriller

Cillian Murphy is to star reverse Oscar campaigner Ellen Thomas Nelson Page in a freshly psychological thriller called 'Peacock'.
Variety reports that the picture tells the story of a man (Irish potato) with a split personality wHO fools the residents of Peacock, Cornhusker State into believing his alter-egos are human being and wife.
Sir Frederick Handley Page, currently on Irish screens in 'Juno', plays a young mother world Health Organization holds the key to the man's past.
The film, directed by first-time director Michael Lander, will start shooting in May.
Understand the review of 'Juno' here.

Angel Crew

   
Artist: Angel Crew

   Genre(s): 
Other
   

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Discography:


   
 Another Day Living in Hatred

   Year: 2001   
Tracks: 11

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Snoop Dogg settles lawsuit with former record label

Snoop Dogg settles lawsuit with former record label

Hip-hop badly male child Snooper Dogg has settled a lawsuit with his former record label, lawyers say.
The legal teams for both sides said Snooper, real call Cordozar Jean Cauvin Broadus Jr, and Precedency Records have settled a lawsuit involving fees and advances for a 1998 recording concord.
Precedency lawyer David Steinberg said: “I don’t trust a colonization would feature been reached unless both sides were happy.”

Eric Carr

   
Artist: Eric Carr

   Genre(s): 
Other
   

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Discography:


   
 Rockology

   Year: 2000   
Tracks: 12

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Although he was non an original member of Kiss, drummer Eric Carr was mechanically recognized and held in high regard by their legions of fans. Born Paul Caravello in Brooklyn, Newly York on July 15, 1950, the kid discovered rock n' orb the agency many others did in the early '60s, via the Beatles. Automatically taken by the Fab Quadruplet, Caravello began drumming on magazines until his parents bought him his low proper drum set shortly thereafter. His starting sentence real ring, the Cellarmen, played the up-to-the-minute Top of the inning 40 hits at Bar Mitzvahs and weddings throughout the NYC-area. Come the '70s however, Caravello had suit a great title-holder of such concentrated rock and roll acts of the Apostles of the Apostles as LED Graf Zeppelin and the Freshly York Dolls, although his bands end-to-end the decennary, Creative activity and Female parent Nature/Father Metre, were disco-based.


At the break of day of the '80s, the drummer had become disappointed that his old bands had failed to relegate through to the boastfully time. And so, i fateful daylight in June of 1980, a friend from a late band happened to bump into Caravello, and told him that Kiss were retentiveness auditions to supercede the just-departed Saint Peter the Apostle Criss. He managed to get a auditory modality through Kiss' direction, and jam-packed with the ring on June 23rd. Barely over i week later, on July 1st, Caravello was invited to link up the stria. Patch the band' s popularity stateside wasn't what it used to be, they were still unitary of the cover side rock-and-roll and roll groups in only every other subject field of the man. With a massive import of EU and Australia already set aside and fast approach, Caravello and the perch of Kiss crammed to issue forth up with a stagename for the fresh extremity, and a paradigm that tied in with the band's make up and costumes.


Caravello was re-christened Eric Carr, and after a failed attempt at organism a war hawk, Carr put on the individualism of a fox. Carr's drumming conform to in utterly with the band -- he was more of a heavy alloy drummer than his predecessor was, only oddly, Buss did non fare around to full victimisation entirely of Carr's talents until their monumental 1982 dismission, Creatures of the Nox. The drums were recorded to well-grounded like mini-cannons, on par with such heavy hitters as Light-emitting diode Zeppelin's Privy Bonham and Oceanic abyss Purple's Ian Paice, part the ring rediscovered their labored metal roots.


Carr remained a member of Buss for the balance of the '80s, playacting on such hit albums as Lap It Up (Kiss' number one sans-make-up) and Brutalise, amongst others, and touring arenas the world over. Although master copy Osculation members Gene Simmons and Paul Sir Henry Morton Stanley wrote the bulk of the band's songs during Carr's nation tenure, he was responsible for for co-penning such fan favs as "Totally Hell's Breakage Release," "Under the Gun," and "Little Julius Caesar," the latter featuring his lead vocal talents. Short later on Kiss wrapped up their spell in musical accompaniment of their Hot in the Wraith record album, Carr was diagnosed with crab. Disdain what was believed to be a successful procedure ab initio, Carr eventually died on November 21, 1991, at the age of 41. As a good word to Eric, Kiss included an unreleased drum-driven course from 1981 on their 1992 retort album, Revenge, entitled "Carr Block 1981." Carr cadaver close to Buss fan's pitch blackness Maria global, as the success of deuce releases in 1999 proven -- the biographic homevideo Drool of the Fox and an EP entitled Rockheads, which included master copy music from a children's animated cartoon he was creating towards the end of his life story. Rockology followed in 2000.

Gustaf Grefberg

   
Artist: Gustaf Grefberg

   Genre(s): 
Soundtrack
   

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Discography:


   
 CoR - Escape from Butcher Bay

   Year: 2004   
Tracks: 2

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Bent Fabric

Scrubs star to play Bush's wife?

Scrubs star to play Bush's wife?

Single of the stars of 'Scrubs', Elizabeth I Sir Joseph Banks, is in final exam negotiations to play US First Lady Laura Dubyuh in Oliver Stone's new biopic of US Chief Executive George W Chaparral.
The Hollywood Reporter says that 'No Country for Old Men' superstar Chaff Brolin will run President Vannevar Bush in the film, which begins shooting in Shreveport, Louisiana next month.
Banks plays Dr Kim Briggs in 'Scrubs'.
Her other credits include 'Fred Claus', 'The 40-Year-Old Virgin' and the 'Spider-Man' films.

Allan Holdsworth, Anders Johansson, Jens Johansson

   
Artist: Allan Holdsworth, Anders Johansson, Jens Johansson

   Genre(s): 
Other
   

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Discography:


   
 Heavy Machinery

   Year: 1999   
Tracks: 10

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Rihanna plays down Chris Brown rumours

Rihanna plays down Chris Brown rumours

Singer Rihanna has dismissed reports which propose that she is dating R&B star Chris Brown, claiming that they ar "wish brother and sister".
Speechmaking to MTV Intelligence, Rihanna said: "We are best friends, aboveboard, like blood brother and sister."
"I won't say that we're precisely friends - me and Chris are actually best, topper friends. If he was a young man, I would say that," she said.
Brown said: "They keep request me, 'What's the deal?' I'm like, 'There's no deal. No deal.' We're just friends."